A workshop at Temple University on Friday, May 4, 2018

This workshop brings together a diverse group of computational scientists to discuss, in a hands-on fashion, challenges and recent developments in the various co-evolution approaches with a foundation in statistical mechanics being used to mine information from protein multiple sequence alignments.

Mutational correlation patterns offer the intriguing opportunity to infer protein fitness landscapes and relate them to protein structures and free energy landscapes. We believe that these methods hold promise for deepening our understanding of the connections between protein sequence, structure, and function maintained through evolution.